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Ask A Greenwitch
Ask a Witch
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Sat, 17 Mar 2007
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 Cannabis use to combat chronic pain
A common obstacle in clinical management of
pathological pain is the poor response to opioid
analgesics. We now report that delta9-
tetrahydrocannabinol (delta9-THC)-induced
antinociception remained effective in rats with
pathological pain. The selective central
cannabinoid receptor antagonist SR141716A, but not
the generic opioid receptor antagonist naloxone,
blocked the delta9-THC antinociception. Moreover,
there is no cross-tolerance between the
antinociceptive effects of morphine and delta9-THC
in pathological pain states. The results indicate
that delta9-THC antinociception is both effective
and independent of opioid receptors in rats with
pathological pain. Thus, the cannabinoid analgesic
system may be superior to opioids in alleviating
intractable pathological pain syndromes.
Posted 08:24
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